Anime: Fullmetal Alchemist
After losing their mother, Alphonse and Edward Elric attempt to bring her back using the forbidden science of human alchemy. However, alchemy operates on the theory of equivalent trade, and breaking the human alchemy taboo carries a heavy price. Ed loses his leg, and Al loses his body. Ed is able to seal Als soul inside of a huge suit of armor, at the cost of his arm. Years later, Ed (now with two mechanical limbs) and Al (still trapped in the armor) leave their childhood home, each brother concerned with the others happiness.
Ed, who has a natural talent and skill for alchemy, becomes nationally certified and is soon known everywhere as the Fullmetal Alchemist. Their true objective is to search for any information on the fabled Philosophers Stone, hoping it will allow them to regain their old bodies. All of their hopes rest with this mythical stone, which may not even exist at all. However, the brothers soon learn that they are not the only ones after the powerful stone.